Lo & Sons — The T.T.
The T.T. ($260) is a larger version of the Brookline, but it can't quite fit a full change of clothes. It has a slimmer profile, so the bag can carry a magazine, notebook, laptop, tablet, makeup bag, and other small doodads snugly.
Unlike The Brookline, there are two main compartments. A large padded slip for a laptop and a smaller padded slip for an ereader are designed to protect your tech. It's currently sold out, so you'll have to join a wait list.
Source: Lo and Sons